Authors: Bowser, Corinna S.; Kaye, Jean; Joks, Rauno O.; Charlot, Cascy-Arnoux; Jack Moallem, H.
Source: Pediatric Allergy and Immunology, Volume 18, Number 4, June 2007 , pp. 298-303(6)
Publisher: Blackwell Publishing
Bowser CS, Kaye J, Joks RO, Charlot C-A, Moallem HJ. IgE and atopy in perinatally HIV-infected children.
Pediatr Allergy Immunol 2007: 18: 298-303. © 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard
Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy is reported in patients infected with human immunodeficiency virus (HIV). The elevated serum IgE may be attributed to polyclonal stimulation of B cells or IgE production against allergens, viruses, fungi and bacteria. This study investigates the prevalence of atopy in perinatally HIV-infected children, and the relationships between serum IgE (and other serum immunoglobulins) with atopy, CD4+ cell count and HIV-disease stage. Serum immunoglobulin levels, epicutaneous skin test for common aeroallergens, clinical Centers for Disease Control and Prevention (CDC) classification, CD4+ cell counts and allergy history were extracted from the charts of perinatally HIV-infected children on highly active antiretroviral therapy. The prevalence of atopy (52%) and the pattern of aeroallergen sensitivity were comparable with the US pediatric population. Serum IgE levels did not correlate with clinical disease stage. However, in non-atopic patients, serum IgE levels increased with disease progression (p = 0.02). There was an inverse relationship between the prevalence of elevated serum IgE levels and atopy with progression of disease (p = 0.019). Serum IgE did not correlate with atopy, CD4+ cell count, or duration of HIV infection or levels of serum immunoglobulins. This is the first study to show no increased prevalence of atopy in perinatally HIV-infected children compared with the general population. In advanced stages of HIV, elevated serum IgE may be specific for antigens other than those known as allergens.
Document Type: Research article
FIGHT AGAINST AIDS, SAVE INDONESIAN CHILDREN
JL TAMAN BENDUNGAN ASAHAN 5 JAKARTA PUSAT, JAKARTA INDONESIA 10210
PHONE :62 (021) 70081995 – 5703646
Email : firstname.lastname@example.org
Clinical and Editor in Chief :
DR WIDODO JUDARWANTO
email : email@example.com,
Copyright © 2009, FIGHT AGAINST AIDS, SAVE INDONESIAN CHILDREN Information Education Network. All rights reserved.