Posted by: Indonesian Children | August 15, 2009

IgE and atopy in perinatally HIV-infected children

Authors: Bowser, Corinna S.; Kaye, Jean; Joks, Rauno O.; Charlot, Cascy-Arnoux; Jack Moallem, H.

Source: Pediatric Allergy and Immunology, Volume 18, Number 4, June 2007 , pp. 298-303(6)

Publisher: Blackwell Publishing

 

Abstract:

Bowser CS, Kaye J, Joks RO, Charlot C-A, Moallem HJ. IgE and atopy in perinatally HIV-infected children. 

Pediatr Allergy Immunol 2007: 18: 298-303. © 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard 

Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy is reported in patients infected with human immunodeficiency virus (HIV). The elevated serum IgE may be attributed to polyclonal stimulation of B cells or IgE production against allergens, viruses, fungi and bacteria. This study investigates the prevalence of atopy in perinatally HIV-infected children, and the relationships between serum IgE (and other serum immunoglobulins) with atopy, CD4+ cell count and HIV-disease stage. Serum immunoglobulin levels, epicutaneous skin test for common aeroallergens, clinical Centers for Disease Control and Prevention (CDC) classification, CD4+ cell counts and allergy history were extracted from the charts of perinatally HIV-infected children on highly active antiretroviral therapy. The prevalence of atopy (52%) and the pattern of aeroallergen sensitivity were comparable with the US pediatric population. Serum IgE levels did not correlate with clinical disease stage. However, in non-atopic patients, serum IgE levels increased with disease progression (p = 0.02). There was an inverse relationship between the prevalence of elevated serum IgE levels and atopy with progression of disease (p = 0.019). Serum IgE did not correlate with atopy, CD4+ cell count, or duration of HIV infection or levels of serum immunoglobulins. This is the first study to show no increased prevalence of atopy in perinatally HIV-infected children compared with the general population. In advanced stages of HIV, elevated serum IgE may be specific for antigens other than those known as allergens.

Keywords: human immunodeficiency virus (HIV); AIDS; IgE; atopy; allergy; immunoglobulin; CD4+ T cell; children; immediate hypersensitivity skin testing

Document Type: Research article

DOI: 10.1111/j.1399-3038.2006.00522.x

 

 

Supported by

FIGHT AGAINST  AIDS, SAVE  INDONESIAN CHILDREN

YUDHASMARA FOUNDATION

JL TAMAN BENDUNGAN ASAHAN 5 JAKARTA PUSAT, JAKARTA INDONESIA 10210

PHONE :62 (021) 70081995 – 5703646

Email : judarwanto@gmail.com 

https://childrenhivaids.wordpress.com/

 

Clinical and Editor in Chief :

DR WIDODO JUDARWANTO

email : judarwanto@gmail.com,

 

Copyright © 2009,  FIGHT AGAINST  AIDS, SAVE  INDONESIAN CHILDREN  Information Education Network. All rights reserved.


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