Posted by: Indonesian Children | August 15, 2009

CD8 + T Lymphocytes Provide Helper Activity for IgE Synthesis in Human Immunodeficiency Virus-infected Patients with Hyper-IgE

Brief DeJfinitive Report

CD8 + T Lymphocytes Provide Helper Activity for IgE Synthesis in Human Immunodeficiency Virus-infected Patients with Hyper-IgE

By Roberto Paganelli, Enrico Scala, Ignacio J. Ansotegui,

Clara M. Ausiello,* Eva Halapi,$ Emanuele Fanales-Belasio,

Giampiero D’Offizi, Ivano Mezzaroma, Franco Pandolfi,$

Massimo Fiorilli, Antonio Cassone,* and Fernando Aiuti

From the Department of Clinical Medicine, Section of Clinical Immunology and Allergy,

University of Rome “La Sapienza” 00185 Rome, Italy; the *Laboratory of Bacteriology and

Medical Mycology, Istituto Superiore di SanitY, 00161 Rome, Italy; the tDepartment of

Immunology, Karolinska Institute, S-I0401 Stockholm, Sweden; and the ~Chair of Metodologia

Clinica, Catholic University, 00168 Rome, Italy

 

Summary

Increased levels of serum IgE and eosinophilia have been described in human immunodeficiency virus (HIV) infection, almost exclusively in patients with CD4 + cell count <200 cells//zl. IgE production is regulated by CD4 + T helper type 2 (Th-2) lymphocytes, producing interleukin 4 (IL-4) and expressing a ligand for the B cell-specific CD40 molecule (CD40 ligand [L]). A shift to a Th-2-1ike pattern of cytokine secretion has been postulated to be associated with progression toward acquired immunodeficiency syndrome (AIDS). We studied three AIDS patients with very high levels of IgE and almost complete depletion of CD4 + lymphocytes, suggesting that IgE synthesis could not be driven by CD4 + cells. IgE in vitro synthesis by cells from such patients was, however, inhibited by anti-IL-4. We show that both CD8 + T cell lines and the majority of CD8 + T cell clones derived from these patients produce IL-4, IL-5, and IL-6 in half of the cases together with interferon “y (IFN-3′). 44% of CD8 § T cell clones expressed a CD40L, and the supernatants of the clones were capable of inducing IgE synthesis by normal B cells costimulated with anti-CD40. CD8 + T cells in these patients therefore functionally mimic Th-2 type cells and may account for hyper-IgE and eosinophilia in the absence of CD4 + cells. The presence of such CD8 + cells may also provide a source of IL

 

 

Supported by

FIGHT AGAINST  AIDS, SAVE  INDONESIAN CHILDREN

YUDHASMARA FOUNDATION

JL TAMAN BENDUNGAN ASAHAN 5 JAKARTA PUSAT, JAKARTA INDONESIA 10210

PHONE :62 (021) 70081995 – 5703646

Email : judarwanto@gmail.com 

https://childrenhivaids.wordpress.com/

 

Clinical and Editor in Chief :

DR WIDODO JUDARWANTO

email : judarwanto@gmail.com,

 

Copyright © 2009,  FIGHT AGAINST  AIDS, SAVE  INDONESIAN CHILDREN  Information Education Network. All rights reserved.


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Categories

%d bloggers like this: